Flucytosine, Fluorouracil, Knife game

ʻO Flucytosine: ʻO Flucytosine , i ʻike ʻia ʻo 5-fluorositosin ( 5-FC ), he lāʻau antifungal. Hoʻohana kikoʻī ʻia ia, me amphotericin B, no nā maʻi maʻi Candida koʻikoʻi a me ka cryptococcosis. Hiki ke hoʻohana ʻia e ia iho a i ʻole me nā antifungals ʻē aʻe no chromomycosis. Hoʻohana ʻia ʻo Flucytosine e ka waha a me ka pahu ʻana i loko o kahi aa.
Fluorouracil: ʻO Fluorouracil ( 5-FU ), kūʻai ʻia ma lalo o ka inoa ʻo Adrucil i waena o nā mea ʻē aʻe, kahi lāʻau chemotherapy i hoʻohana ʻia e mālama ai i ka maʻi ʻaʻai. Ma ka pahu ʻana i loko o kahi aa koko ua hoʻohana ʻia ia no ka maʻi ʻaʻai kolona, ​​maʻi ʻaʻai esophageal, maʻi ʻaʻai ʻōpū, maʻi ʻaʻai pancreatic, umauma maʻi ʻaʻai, a me ka maʻi ʻaʻa ʻiwi. Ma ke ʻano he kalima e hoʻohana ʻia no ka keratosis actinic, ka maʻi ʻaʻa basal cell, a me nā warts ʻili.
Pāʻani pahi: ʻO ka pāʻani pahi , pinfinger , nerve , pīhopa , kui kuʻi , nā manamana lima pahi , pahi ʻokiʻoki , ʻelima mau ʻūlima manamana lima ( FFF ), a i ʻole " kui i waena o nā pāʻani manamana lima ", kahi pāʻani kahi e waiho ana ka poho o ka lima i lalo i ka papa me nā manamana lima. kaawale, me ka hoʻohana ʻana i ka pahi, a i ʻole mea ʻē aʻe ʻē aʻe, hoʻāʻo kekahi e hou i hope a ma waena ma waena o nā manamana lima, e hoʻoneʻe ana i ka mea i hope a i mua hoʻi, e hoʻāʻo ana ʻaʻole e paʻi i kekahi manamana Hoʻoweliweli ʻino ka pāʻani, e hōʻike ana i nā mea pāʻani i ka makaʻu o ka ʻeha a me ka scarring, a, ma mua o nā lāʻau ʻalopika, he incision a penetration paha i makaʻu sepsis a me ka make. Hāpai kahi lau hikiwawe i ka makaʻu hou aʻe, "ʻoiai ke wikiwiki ʻoe e hele, e pelu hou ka pahi i loko ona e paʻa ana i ka manamana o kou lima hou." Hiki paha ke pāʻani keu aku me ka palekana me ka hoʻohana ʻana i kahi mea ʻē aʻe, e like me ka ʻaoʻao eraser o kahi penikala a i ʻole kahi māka me kona pāpale. I ka moʻomeheu ʻEulopa ua manaʻo ʻia he pāʻani mau keikikāne. Eia nō naʻe, ke nānā aku nei i ka hoʻonohonoho ʻana o ka kaʻa a me ka dexterity e hoʻohālikelike ʻia i nā pāʻani paʻipaʻi. Ma waena o kā mākou leʻaleʻa rowdy [exiled in Siberia] kahi pāʻani pahi kaulana. Kau ʻoe i ka poho o kou lima ma ka papa me ka manamana ʻokoʻa. A laila hou ʻoe i hope ma waena o nā manamana lima, e hoʻāʻo nei ʻaʻole e pā iā lākou. ʻO ka wikiwiki o ka hou, ʻo ka ʻoi aku ka maikaʻi, a ʻo ka mea wikiwiki loa e lanakila. He ʻili maka kaʻu e ʻike ʻia ... ma ke ʻano he hoʻomanaʻo no kēia pāʻani. ʻAʻole maopopo iaʻu ke kumu a mākou i hana ai i kahi mea kolohe, akā me he mea lā he kāne e hana i kēlā manawa. He mea macho ka loaʻa ʻana o ka jacknife i koʻu wā ʻōpio [i North Dakota] a ʻoi aku ka manlier e pāʻani pū me ia i nā pāʻani weliweli. ʻO kekahi o kā mākou pāʻani ʻeke ʻeke ka ... mumbly-peg .... Kāhea ʻia kahi pāʻani weliweli ʻo Knife Game, a ʻo kekahi manawa ʻo FFF ka inoa. Ua hoʻokūkū kēia pāʻani i kāu hoʻohui ʻana i kou hoʻāʻo ʻana e hou i kahi pahi ma waena o kou mau manamana lima kīnā ʻia ʻoiai e paʻa ana i kou poho lima i ka honua a i kahi papa. ʻO ka mea hiki ke hana i kēlā mea wikiwiki loa i ka manawa i hāʻawi ʻia ʻo ia ka mea lanakila. ʻO ka mea nalo ka lohi loa - a i ʻole nāna i hou i kona lima a i ʻole ka manamana lima. ʻO wau ka mea nalowale nui i kekahi manawa, ... ua waiho ia kahi mālamalama maopopo ... e hōʻike ana i ka hōʻoia o nā loina e hōʻoia ana i ke kāne.
5-Fluoro-5-deoxy-D-ribose 1-phosphate: 5-Fluoro-5-deoxy- d -ribose 1-phosphate kahi metabolite i hana ʻia i ka wā o ka biosynthesis o organofluorides. Hoʻokumu ʻia ia e ka purine nucleoside phosphorylase i waena o ka phosphorolytic cleavage o 5'-deoxy-5'-fluoroadenosine. Hoʻokomo ʻia ia i 5-fluoro-5-deoxy-ribulose-1-phosphate a laila hoʻopaʻa ʻia e kahi aldolase e hoʻokuʻu i ka fluoroacetaldehyde.
5-Fluoro-5-deoxy-D-ribose 1-phosphate: 5-Fluoro-5-deoxy- d -ribose 1-phosphate kahi metabolite i hana ʻia i ka wā o ka biosynthesis o organofluorides. Hoʻokumu ʻia ia e ka purine nucleoside phosphorylase i waena o ka phosphorolytic cleavage o 5'-deoxy-5'-fluoroadenosine. Hoʻokomo ʻia ia i 5-fluoro-5-deoxy-ribulose-1-phosphate a laila hoʻopaʻa ʻia e kahi aldolase e hoʻokuʻu i ka fluoroacetaldehyde.
5-Fluoro-AMT: ʻO 5-Fluoro-α-methyltr Egyptamine ( 5-Fluoro-αMT ), i ʻike ʻia ʻo PAL-544 , kahi mea hoʻonāukiuki putative, entactogen, a me psychedelic tryptamine derivative e pili ana i ka α-methyltr Egyptamine (αMT). Ua ʻike ʻia e hana ma ke ʻano he kaulike hoʻokuʻu serotonin-norepinephrine-dopamine, he agonist nā mea loaʻa he 5-HT 2A , a he mea kāohi MAO-A ikaika a kikoʻī hoʻi. Hana ia i kahi pane poʻo-twitch ikaika i nāʻiole, a ʻike ʻia kēia hopena e hoʻopili me nā hopena psychedelic i loko o nā kānaka, e hōʻike nei he 5-fluoro-αMT hiki ke lilo i psychedelic hana i loko o nā kānaka, ʻoiai ʻaʻole ʻike ʻia ua hoʻāʻo ʻia i kānaka a hiki ke weliweli ma muli o ka ikaika o ka pāpā ʻana o MAO-A.
5-Fluoro-DMT: 5-Fluoro- N , N -dimethyltr Egyptamine ( 5-fluoro-DMT ) kahi pākana tryptamine e pili ana i nā pūhui e like me 5-bromo-DMT a me 5-MeO-DMT. ʻO ka Fluorination o nā tryptamines psychedelic e hoʻoliʻiliʻi a i ʻole hopena iki ma ka 5-HT 2A / C receptor affinity a i ʻole ka hana intrinsic, ʻoiai he hana ʻole ʻo 6-fluoro-DET ma ke ʻano he psychedelic me ka hana ʻana ma ke ʻano he agonist 5-HT 2A , ʻoiai 4-fluoro-5 -methoxy-DMT kahi agonist ʻoi aku ka ikaika ma 5-HT 1A ma mua o 5-HT 2A .
5-Fluoro-AMT: ʻO 5-Fluoro-α-methyltr Egyptamine ( 5-Fluoro-αMT ), i ʻike ʻia ʻo PAL-544 , kahi mea hoʻonāukiuki putative, entactogen, a me psychedelic tryptamine derivative e pili ana i ka α-methyltr Egyptamine (αMT). Ua ʻike ʻia e hana ma ke ʻano he kaulike hoʻokuʻu serotonin-norepinephrine-dopamine, he agonist nā mea loaʻa he 5-HT 2A , a he mea kāohi MAO-A ikaika a kikoʻī hoʻi. Hana ia i kahi pane poʻo-twitch ikaika i nāʻiole, a ʻike ʻia kēia hopena e hoʻopili me nā hopena psychedelic i loko o nā kānaka, e hōʻike nei he 5-fluoro-αMT hiki ke lilo i psychedelic hana i loko o nā kānaka, ʻoiai ʻaʻole ʻike ʻia ua hoʻāʻo ʻia i kānaka a hiki ke weliweli ma muli o ka ikaika o ka pāpā ʻana o MAO-A.
5-Fluoro-AMT: ʻO 5-Fluoro-α-methyltr Egyptamine ( 5-Fluoro-αMT ), i ʻike ʻia ʻo PAL-544 , kahi mea hoʻonāukiuki putative, entactogen, a me psychedelic tryptamine derivative e pili ana i ka α-methyltr Egyptamine (αMT). Ua ʻike ʻia e hana ma ke ʻano he kaulike hoʻokuʻu serotonin-norepinephrine-dopamine, he agonist nā mea loaʻa he 5-HT 2A , a he mea kāohi MAO-A ikaika a kikoʻī hoʻi. Hana ia i kahi pane poʻo-twitch ikaika i nāʻiole, a ʻike ʻia kēia hopena e hoʻopili me nā hopena psychedelic i loko o nā kānaka, e hōʻike nei he 5-fluoro-αMT hiki ke lilo i psychedelic hana i loko o nā kānaka, ʻoiai ʻaʻole ʻike ʻia ua hoʻāʻo ʻia i kānaka a hiki ke weliweli ma muli o ka ikaika o ka pāpā ʻana o MAO-A.
5F-CUMYL-P7AICA: ʻO 5F-CUMYL-P7AICA kahi pyrrolo [2,3-b] pyridine-3-carboxamide i hoʻokumu ʻia i ka cannabinoid synthetic i kūʻai ʻia ma ke ʻano he lāʻau hoʻolālā. Ua ʻike ʻia ia e ka EMCDDA ma Pepeluali 2015.
5F-MDMB-PICA: ʻO 5F-MDMB-PICA kahi lāʻau hoʻolālā a me ka cannabinoid synthetic. I ka makahiki 2018, ʻo ia ka ʻelima o ka cannabinoid synthetic synthetic i ʻike ʻia i nā lāʻau i hopu ʻia e ka Drug Enforcement Administration.
ʻO Flucytosine: ʻO Flucytosine , i ʻike ʻia ʻo 5-fluorositosin ( 5-FC ), he lāʻau antifungal. Hoʻohana kikoʻī ʻia ia, me amphotericin B, no nā maʻi maʻi Candida koʻikoʻi a me ka cryptococcosis. Hiki ke hoʻohana ʻia e ia iho a i ʻole me nā antifungals ʻē aʻe no chromomycosis. Hoʻohana ʻia ʻo Flucytosine e ka waha a me ka pahu ʻana i loko o kahi aa.
Fluorodeoxyuridylate: ʻO Fluorodeoxyuridylate, ʻike ʻia ʻo FdUMP, 5-Fluoro-2'-deoxyuridylate, a i ʻole 5-Fluoro-2'-deoxyuridine 5'-monophosphate sodium paʻakai, kahi mole i hana ʻia i vivo mai 5-fluorouracil a i ʻole 5-fluorodeoxyuridin.
5-Fluoroorotic acid: ʻO 5-Fluoroorotic acid ( 5FOA ) kahi mea i loaʻa mai i ka pyrimidine precursor orotic acid. Hoʻohana ʻia ia i nā genetics hū e koho ai no ka loaʻa ʻole o ka gen URA3, kahi e hoʻopili ai i ka enzyme no ka decarboxylation o 5-fluoroorotic acid i 5-fluorouracil, kahi metabolite ʻona.
5-Fluoroorotic acid: ʻO 5-Fluoroorotic acid ( 5FOA ) kahi mea i loaʻa mai i ka pyrimidine precursor orotic acid. Hoʻohana ʻia ia i nā genetics hū e koho ai no ka loaʻa ʻole o ka gen URA3, kahi e hoʻopili ai i ka enzyme no ka decarboxylation o 5-fluoroorotic acid i 5-fluorouracil, kahi metabolite ʻona.
Fluorouracil: ʻO Fluorouracil ( 5-FU ), kūʻai ʻia ma lalo o ka inoa ʻo Adrucil i waena o nā mea ʻē aʻe, kahi lāʻau chemotherapy i hoʻohana ʻia e mālama ai i ka maʻi ʻaʻai. Ma ka pahu ʻana i loko o kahi aa koko ua hoʻohana ʻia ia no ka maʻi ʻaʻai kolona, ​​maʻi ʻaʻai esophageal, maʻi ʻaʻai ʻōpū, maʻi ʻaʻai pancreatic, umauma maʻi ʻaʻai, a me ka maʻi ʻaʻa ʻiwi. Ma ke ʻano he kalima e hoʻohana ʻia no ka keratosis actinic, ka maʻi ʻaʻa basal cell, a me nā warts ʻili.
5-Fluorowillardiine: ʻO 5-Fluorowillardiine kahi agonist koho no ka receptor AMPA, me nā hopena palena palena wale i ka kainate receptor. He neurotoxin excitotoxic ke hoʻohana ʻia i loko o ka vivo a no laila ʻaʻole hoʻohana pinepine ʻia i nā holoholona paʻa, akā hoʻohana nui ʻia ia e hoʻouluulu selectively i nā mea lawe AMPA i vitro . Kūlike like ia me ka willardiine hui, a he agonist hoʻi ia no ka AMPA a me nā reseptor kainate. Kūlohelohe ʻo Willardiine ma Mariosousa willardiana a me Acacia sensu lato.
Fluorouracil: ʻO Fluorouracil ( 5-FU ), kūʻai ʻia ma lalo o ka inoa ʻo Adrucil i waena o nā mea ʻē aʻe, kahi lāʻau chemotherapy i hoʻohana ʻia e mālama ai i ka maʻi ʻaʻai. Ma ka pahu ʻana i loko o kahi aa koko ua hoʻohana ʻia ia no ka maʻi ʻaʻai kolona, ​​maʻi ʻaʻai esophageal, maʻi ʻaʻai ʻōpū, maʻi ʻaʻai pancreatic, umauma maʻi ʻaʻai, a me ka maʻi ʻaʻa ʻiwi. Ma ke ʻano he kalima e hoʻohana ʻia no ka keratosis actinic, ka maʻi ʻaʻa basal cell, a me nā warts ʻili.
5-Formamidoimidazole-4-carboxamide ribotide: ʻO 5-Formamidoimidazole-4-carboxamide ribotide kahi mea waena i ka hoʻokumu ʻia o nā purine. Hana ʻia e ka enzyme AICAR transformylase mai AICAR a me 10-formyltetrahydrofolate.
5-Formiminotetrahydrofolate: 5-Formiminotetrahydrofolate kahi mea waena i ka catabolism o histidine. Hana ʻia e glutamate formimidoyltransferase a laila hoʻololi ʻia i 5,10-methenyltetrahydrofolate e formiminotransferase cyclodeaminase.
5-Formylcytosine: ʻO 5-Formylcytosine (5fC) kahi kumu nitrogen pyrimidine i loaʻa mai ka cytosine. I loko o ka pōʻaiapili o ke kemika acidic nukelika a me ka biology, ʻike ʻia ia me he māka epigenetic. ʻIke ʻia i ka makahiki 2011 ma nā mamele embryonic stem cells e ka hui noiʻi a Thomas Carell ua hōʻoia hou ʻia ka nukleoside i hoʻololi ʻia e pili pū kekahi ma ke ʻano he waena ma ke ala demethylation ʻeleu a ma ke ʻano he marker epigenetic kū hoʻokahi. I nā māmela, hana ʻia ʻo 5fC e ka hoʻowali ʻia o 5-Hydroxymethylcytosine (5hmC) kahi hopena i hoʻopili ʻia e nā enzyme TET. ʻO C 5 H 5 N 3 O 2 ke ʻano o kona molaki.
Folinic acid: ʻO ka waikawa Folinic , i kapa ʻia hoʻi ʻo leucovorin , kahi lāʻau i hoʻohana ʻia e hōʻemi i nā hopena ʻawahia o methotrexate a me pyrimethamine. Hoʻohana pū ʻia ia me ka 5-fluorouracil e mālama ai i ka maʻi ʻaʻai colorectal a me ka maʻi ʻaʻai pancreatic, hiki ke hoʻohana ʻia e mālama i ka hemahema folate e hopena ai i ka anemia, a me ka lāʻau make methanol. Lawe ʻia e ka waha, ʻoki ʻana i loko o kahi mākala, a i ʻole ka ʻomo ʻana i loko o kahi aa.
5-Formyluracil: ʻO 5-Formyluracil kahi kumu kumu lāʻau heterocyclic. Hana ʻia ia mai ka oxidation o ka hui methyl o thymine. He mutagenic ia.
5G: I ke kelepona ʻana, ʻo 5G ka ʻenehana hanauna ʻelima hanauna no nā pūnaewele pūnaewele broadband, kahi a nā hui kelepona paʻalima i hoʻomaka ai e hoʻouka i ka honua holoʻokoʻa ma ka makahiki 2019, a ʻo ia ka mea i hoʻolālā ʻia i hope no nā pūnaewele 4G e hāʻawi i ka pilina i nā kelepona paʻalima hou. Ua wānana ʻia nā pūnaewele 5G ma mua o 1.7 biliona o nā mea kau inoa ma ka honua holoʻokoʻa e 2025, e like me ka GSM Association. E like me nā mea ma mua, he mau pūnaewele pūnaewele nā ​​pūnaewele 5G, kahi i māhele ʻia ai ka wahi lawelawe i nā wahi ʻāina liʻiliʻi i kapa ʻia nā hunaola . Pili nā pūnaewele uea ʻole 5G āpau i ka Pūnaewele a me ka pūnaewele kelepona e nā nalu lekiō ma o ka antenna kūloko i loko o ka pūnaewele. ʻO ka pōmaikaʻi nui o nā pūnaewele hou e loaʻa iā lākou ka bandwidth nui aʻe, e hāʻawi ana i nā wikiwiki hoʻoiho kiʻekiʻe, a hiki i 10 gigabits i kēlā me kēia kekona (Gbit / s). Ma muli o ka hoʻonui ʻia o ka bandwīwī, manaʻo ʻia ʻaʻole e lawelawe wale nā ​​pūnaewele i nā kelepono e like me nā pūnaewele pūnaewele e kū nei, akā e hoʻohana pū ʻia me nā mea lawelawe pūnaewele maʻamau no nā kamepila laptops a me nā kamepiula kamepiula, e hoʻokūkū ana me nā ISP e like me ke kelepona uila, a e hiki nō hoʻi nā polokalamu hou i ka pūnaewele o nā mea (IoT) a me ka mīkini i nā wahi mīkini. ʻAʻole hiki i nā kelepona paʻalima 4G ke hoʻohana i nā pūnaewele hou, e koi ana i nā hāme uila uila ʻole 5G.
5-Geranyloxy-7-methoxycoumarin: ʻO 5-Geranyloxy-7-methoxycoumarin kahi coumarin kūlohelohe me ka mole mole C 20 H 24 O 4 . Loaʻa iā ia i nā aila pono o ka citrus e like me bergamot.
5-Geranyloxy-7-methoxycoumarin: ʻO 5-Geranyloxy-7-methoxycoumarin kahi coumarin kūlohelohe me ka mole mole C 20 H 24 O 4 . Loaʻa iā ia i nā aila pono o ka citrus e like me bergamot.
5H: E nānā paha ʻo 5H a i ʻole 5h : ʻO Fifth Harmony, ka hui kaikamahine ʻAmelika 5H, kahi ʻano kēpau i ka penikala SSH 5H (WA), kahi i koho ʻia no Washington State Route 507 Lele540 5 H, kahi isotope paʻa paʻa ʻole o ka hydrogen Ke kūlanakauhale o ka make , kahi kauka 1979 Who serial
5-Hydroxyeicosatetraenoic acid: 5-Hydroxyeicosatetraenoic acid kahi eicosanoid, ʻo ia kahi metabolite o ka waikawa arachidonic. Hana ʻia ia e nā ʻano pūnaewele like ʻole i loko o nā kānaka a me nā ʻano holoholona ʻē aʻe. Hiki i kēia mau hunaola ke hoʻopili i ka 5 ( S ) -HETE i 5-oxo-eicosatetraenoic acid (5-oxo-ETE), 5 ( S ), 15 ( S ) -dihydroxyeicosatetraenoic acid, a i ʻole 5-oxo-15-hydroxyeicosatetraenoic acid .
5-Hydroxyindoleacetic acid: 5-Hydroxyindoleacetic acid (5-HIAA) ka metabolite nui o ka serotonin. I ke kālailai kemika o nā mimi, hoʻohana ʻia ʻo 5-HIAA e hoʻoholo i nā pae serotonin i loko o ke kino.
Hydroxymethylfurfural: ʻO Hydroxymethylfurfural (HMF), ʻo 5- (hydroxymethyl) furfural, kahi hui kūlohelohe i hoʻokumu ʻia e ka dehydration o ka hōʻemi ʻana i nā kō. He paʻa keʻokeʻo haʻahaʻa hoʻoheheʻe keʻokeʻo ia i hiki ke hoʻonā ʻia i nā wai a me nā mea hoʻoheheʻe kūlohelohe. Aia ka mole i ke apo furan, i loko o nā hui ʻelua aldehyde a me nā mea ʻona.
Alpha-Methylserotonin: α-Methylserotonin ( αMS ), ʻike ʻia ʻo α-methyl-5-hydroxytr Egyptamine ( α-methyl-5-HT ) a i ʻole 5-hydroxy-α-methyltr Egyptamine ( 5-HO-αMT ), kahi pākana tryptamine pili loa i ka serotonin neurotransmitter (5-HT). Hana ia ma ke ʻano he agonist receptor serotonin non-selective a ua hoʻohana nui ʻia i ka noiʻi ʻepekema e hoʻopaʻa i ka hana o ka ʻōnaehana serotonin.
ʻO Bufotenin: ʻO Bufotenin kahi huahana tryptamine e pili ana i ka neurotransmitter serotonin. He alkaloid ia i loaʻa i kekahi ʻano o nā toads, nā mea kanu a me nā mea kanu kiʻekiʻe.
5-HO-DiPT: ʻO 5-HO-DiPT ( 5-hydroxy- N, N -di- iso -propyltr Egyptamine ) kahi pākana tryptamine e hana ma ke ʻano he agonist reseptor serotonin. ʻIʻike nui ʻia ia ma ke ʻano he metabolite o ka lāʻau psychoactive ʻo 5-MeO-DiPT i ʻike ʻia, akā ʻo 5-HO-DiPT ʻaʻole i ʻike pinepine ʻia ma ke ʻano he lāʻau hoʻolālā i kāna pono ponoʻī. Hōʻike nā hōʻike ma vitro i ka 5-HO-DiPT e loaʻa kahi pilina 5-HT 2A kiʻekiʻe a me kahi koho maikaʻi ma mua o 5-HT 1A , ʻoiai ʻoi aku ka lipophilic ma mua o ka bufotenine lāʻau e pili ana (5-HO-DMT), kahi e hoʻopuka ai i nā hopena ākea.
Alpha-Methylserotonin: α-Methylserotonin ( αMS ), ʻike ʻia ʻo α-methyl-5-hydroxytr Egyptamine ( α-methyl-5-HT ) a i ʻole 5-hydroxy-α-methyltr Egyptamine ( 5-HO-αMT ), kahi pākana tryptamine pili loa i ka serotonin neurotransmitter (5-HT). Hana ia ma ke ʻano he agonist receptor serotonin non-selective a ua hoʻohana nui ʻia i ka noiʻi ʻepekema e hoʻopaʻa i ka hana o ka ʻōnaehana serotonin.
5-hydroperoxide waikawa Arachidonic: ʻO Arachidonic acid 5-hydroperoxide kahi mea waena i ka metabolism o ka acid arachidonic e ka ALOX5 enzyme i loko o nā kānaka a i ʻole Alox5 enzyme i loko o nā māmela ʻē aʻe. Hoʻopili hou ʻia ka mea waena i: a) leukotriene A4 a laila hoʻopili ʻia i ka mea chemotactic no nā leukosit, leukotriene B4, a i ʻole nā ​​mea hana o nā alaloa ākea, leukotriene C4, leukotriene D4, a me leukotriene E4; b) nā leukocyte chemotactic kumu, 5-Hydroxyicosatetraenoic acid a me 5-oxo-eicosatetraenoic acid; aiʻole c) nā mea hoʻoponopono pro-hoʻonā hoʻonāukiuki o ka līlū, lipoxin A4 a me lipoxin B4.
Serotonin: ʻO Serotonin a i ʻole 5-hydroxytr Egyptamine ( 5-HT ) kahi neurotransmitter monoamine. He paʻakikī a multifaceted kāna hana biology, hoʻololi i ka naʻau, ʻike, uku, aʻo, hoʻomanaʻo, a me nā hanana physiological e like me ka luaʻi a me ka vasoconstriction.
5-HT1 palapala loaʻa: ʻO nā mea loaʻa 5-HT 1 kahi ʻohana o nā mea loaʻa he 5-HT serotonin e hoʻopaʻa ai i ka endotrous neurotransmitter serotonin (ʻo ia hoʻi ʻo 5-hydroxytr Egyptamine, a i ʻole 5-HT). ʻO ka ʻohana 5-HT 1 ʻohana he ʻelima G protein-i hui pū ʻia (GPCRs) i hui ʻia me G i / G o a me waena o ka neurotransmission inhibitory, me 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , a me 5-HT 1F . ʻAʻohe mea loaʻa he 5-HT 1C , ʻoiai ua reclassified e like me ka mea loaʻa iā 5-HT 2C . No ka ʻike hou aku, e ʻoluʻolu e ʻike i nā ʻatikala nui o kēlā me kēia subtypes:
5-HT1A ʻelima: ʻO ka serotonin 1A receptor kahi subtype o ka serotonin receptor, a i ʻole 5-HT receptor, ka mea e hoʻopaʻa ai i ka serotonin, i ʻike ʻia ʻo 5-HT, kahi neurotransmitter. Hōʻike ʻia ʻo 5-HT1A i ka lolo, pelupelu, a me ka puʻukū neonatal. He receptor G hui pū ʻia (GPCR), hui pū ʻia me ka pūmua Gi, a me kāna hoʻoulu ʻana i ka lolo e hoʻopili i ka hyperpolarisation a me ka hoʻemi ʻana o ka helu o ke kī ʻana o ka neuron postsynaptic. I nā kānaka, ua hoʻopili ʻia ka serotonin 1A receptor e ka ʻāpana HTR1A.
ʻO agonist receptor Serotonin: ʻO kahi agonist receptor agonist kahi agonist o hoʻokahi a ʻoi paha o nā serotonin receptor. Hoʻopili lākou i nā mea loaʻa serotonin i kahi ʻano like me ka serotonin, kahi neurotransmitter a me ka hormone a me ka ligand endogenous o nā serotonin receptor.
5-HT1A ʻelima: ʻO ka serotonin 1A receptor kahi subtype o ka serotonin receptor, a i ʻole 5-HT receptor, ka mea e hoʻopaʻa ai i ka serotonin, i ʻike ʻia ʻo 5-HT, kahi neurotransmitter. Hōʻike ʻia ʻo 5-HT1A i ka lolo, pelupelu, a me ka puʻukū neonatal. He receptor G hui pū ʻia (GPCR), hui pū ʻia me ka pūmua Gi, a me kāna hoʻoulu ʻana i ka lolo e hoʻopili i ka hyperpolarisation a me ka hoʻemi ʻana o ka helu o ke kī ʻana o ka neuron postsynaptic. I nā kānaka, ua hoʻopili ʻia ka serotonin 1A receptor e ka ʻāpana HTR1A.
5-HT1B loaʻa: 5-hydroxytr Egyptamine receptor 1B i ʻike ʻia ma ke ʻano he reseptor 5-HT 1B kahi protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR1B . ʻO ka receptor 5-HT 1B kahi subtype receptor 5-HT.
5-HT1B loaʻa: 5-hydroxytr Egyptamine receptor 1B i ʻike ʻia ma ke ʻano he reseptor 5-HT 1B kahi protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR1B . ʻO ka receptor 5-HT 1B kahi subtype receptor 5-HT.
5-HT2C mea loaʻa: ʻO ka receptor 5-HT 2C kahi subtype o ka receptor 5-HT e hoʻopaʻa ana i ka endotrousous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT). ʻO ia kahi mea loaʻa pūmua G hui pū ʻia (GPCR) i hui pū ʻia me G q / G 11 a me nā mea hoʻoliʻiliʻi neurotransmission Hōʻike ka HTR2C i ka hoʻopā'ālua o nā gen kanaka no ka receptor, aia i loko o nā kānaka aia ma ka X chromosome. ʻOiai he kope ko nā kāne kāne i ka ʻāpana a ma nā wahine kekahi o nā kope ʻelua o ka ʻāpana i hoʻopaʻa ʻia, hiki i nā polymorphism ma kēia receptor ke hoʻopili i nā kāne ʻelua i nā ʻokoʻa like ʻole.
5-HT2C mea loaʻa: ʻO ka receptor 5-HT 2C kahi subtype o ka receptor 5-HT e hoʻopaʻa ana i ka endotrousous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT). ʻO ia kahi mea loaʻa pūmua G hui pū ʻia (GPCR) i hui pū ʻia me G q / G 11 a me nā mea hoʻoliʻiliʻi neurotransmission Hōʻike ka HTR2C i ka hoʻopā'ālua o nā gen kanaka no ka receptor, aia i loko o nā kānaka aia ma ka X chromosome. ʻOiai he kope ko nā kāne kāne i ka ʻāpana a ma nā wahine kekahi o nā kope ʻelua o ka ʻāpana i hoʻopaʻa ʻia, hiki i nā polymorphism ma kēia receptor ke hoʻopili i nā kāne ʻelua i nā ʻokoʻa like ʻole.
5-HT1D mea loaʻa: 5-hydroxytr Egyptamine (serotonin) receptor 1D , i ʻike ʻia ʻo HTR1D , he mea loaʻa he 5-HT, akā hōʻike pū kekahi i ka gen kanaka e hoʻopili ana iā ia. Hana ʻo 5-HT 1D ma ka ʻōnaehana ʻōnaehana waena, a hoʻopili i ka locomotion a me ka hopohopo. Hoʻokomo pū ia i ka vasoconstriction vascular i ka lolo.
5-HT1D mea loaʻa: 5-hydroxytr Egyptamine (serotonin) receptor 1D , i ʻike ʻia ʻo HTR1D , he mea loaʻa he 5-HT, akā hōʻike pū kekahi i ka gen kanaka e hoʻopili ana iā ia. Hana ʻo 5-HT 1D ma ka ʻōnaehana ʻōnaehana waena, a hoʻopili i ka locomotion a me ka hopohopo. Hoʻokomo pū ia i ka vasoconstriction vascular i ka lolo.
5-HT1D ʻākena agonist: 5-HT 1D mau agonists nā mea loaʻa nā lāʻau lapaʻau no ka mālama ʻana i ka migraine. Pākuʻi ʻia lākou: Nā Triptans ʻO Ergotamine ʻO Dihydroergotamine, kahi kumu o ka mea ma mua Alniditan
5-HT1E mea loaʻa: 5-hydroxytr Egyptamine (serotonin) 1E reseptor (5-HT 1E ) kahi mea hōʻike nui loa G-protein hui pū ʻia e pili ana i ka ʻohana receptor 5-HT1. Ua kapa ʻia ka moʻokūʻauhau kanaka ma ke ʻano he HTR1E .
5-HT1E mea loaʻa: 5-hydroxytr Egyptamine (serotonin) 1E reseptor (5-HT 1E ) kahi mea hōʻike nui loa G-protein hui pū ʻia e pili ana i ka ʻohana receptor 5-HT1. Ua kapa ʻia ka moʻokūʻauhau kanaka ma ke ʻano he HTR1E .
5-HT1F mea loaʻa: 5-hydroxytr Egyptamine (serotonin) receptor 1F , i ʻike ʻia ʻo HTR1F kahi 5-HT 1 protein protein a hōʻike pū kekahi i ka gen kanaka e hoʻopili ana iā ia.
5-HT1F mea loaʻa: 5-hydroxytr Egyptamine (serotonin) receptor 1F , i ʻike ʻia ʻo HTR1F kahi 5-HT 1 protein protein a hōʻike pū kekahi i ka gen kanaka e hoʻopili ana iā ia.
ʻO agonist receptor Serotonin: ʻO kahi agonist receptor agonist kahi agonist o hoʻokahi a ʻoi paha o nā serotonin receptor. Hoʻopili lākou i nā mea loaʻa serotonin i kahi ʻano like me ka serotonin, kahi neurotransmitter a me ka hormone a me ka ligand endogenous o nā serotonin receptor.
ʻO 5-HT ka mea loaʻa: ʻO nā mea loaʻa ʻo 5-HT , nā mea loaʻa he 5-hydroxytr Egyptamine , a i ʻole nā mea loaʻa serotonin , kahi hui o nā mea loaʻa pū kekahi protein G a me nā kaha ion ligand-gated i loaʻa i nā ʻōnaehana kikowaena a me nā ʻaoʻao āpau. Hoʻopili lākou i nā neurotransmission excitatory a me inhibitory. Hoʻoulu ʻia nā mea hoʻolauna serotonin e ka neurotransmitter serotonin, e hana nei ma ke ʻano he ligand maoli.
5-HT1 palapala loaʻa: ʻO nā mea loaʻa 5-HT 1 kahi ʻohana o nā mea loaʻa he 5-HT serotonin e hoʻopaʻa ai i ka endotrous neurotransmitter serotonin (ʻo ia hoʻi ʻo 5-hydroxytr Egyptamine, a i ʻole 5-HT). ʻO ka ʻohana 5-HT 1 ʻohana he ʻelima G protein-i hui pū ʻia (GPCRs) i hui ʻia me G i / G o a me waena o ka neurotransmission inhibitory, me 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , a me 5-HT 1F . ʻAʻohe mea loaʻa he 5-HT 1C , ʻoiai ua reclassified e like me ka mea loaʻa iā 5-HT 2C . No ka ʻike hou aku, e ʻoluʻolu e ʻike i nā ʻatikala nui o kēlā me kēia subtypes:
5-HT2 mea loaʻa: ʻO nā mea loaʻa 5-HT 2 kahi ʻohana o nā mea loaʻa he 5-HT e hoʻopaʻa ana i ka endotrous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT). ʻO ka ʻohana 5-HT 2 ʻohana he ʻekolu mau ʻāpana protein G i hoʻohui ʻia (GPCRs) i hoʻopili ʻia iā G q / G 11 a me waena o neurotransmission excitatory, me 5-HT 2A , 5-HT 2B , a me 5-HT 2C . No ka ʻike hou aku, e ʻoluʻolu e ʻike i nā ʻatikala nui o kēlā me kēia subtypes:
5-HT2A ʻelima: ʻO ka receptor 5-HT 2A kahi subtype o ka receptor 5-HT 2 e pili ana i ka ʻohana receptor serotonin a he receptor hui pū ʻia me G protein (GPCR). ʻO ka receptor 5-HT 2A kahi mea loaʻa i ka ʻili pūnaewele. Pōkole ʻo 5-HT no 5-hydroxy-tryptamine, ʻo ia ka serotonin. ʻO kēia ka subtype receptor recitatory nui i waena o nā GPCRs no ka serotonin, ʻoiai ʻo 5-HT 2A kekahi hopena hopena i kekahi mau wahi e like me ka cortex ʻike a me ka orbitofrontal Cortex. Hoʻomaopopo mua ʻia kēia mea loaʻa no ka mea nui ma ke ʻano he pahuhopu o nā lāʻau psychedelic serotonergic e like me ka LSD a me ka mushroom psilocybin. Ma hope ua hoʻi hou i ke kūlana kiʻekiʻe no ka mea ua ʻike ʻia e lawelawe ana, i ka hapa iki, i ka hana a nā lāʻau antipsychotic he nui, ʻo ia hoʻi nā mea ʻāpiki.
5-HT2A ʻelima: ʻO ka receptor 5-HT 2A kahi subtype o ka receptor 5-HT 2 e pili ana i ka ʻohana receptor serotonin a he receptor hui pū ʻia me G protein (GPCR). ʻO ka receptor 5-HT 2A kahi mea loaʻa i ka ʻili pūnaewele. Pōkole ʻo 5-HT no 5-hydroxy-tryptamine, ʻo ia ka serotonin. ʻO kēia ka subtype receptor recitatory nui i waena o nā GPCRs no ka serotonin, ʻoiai ʻo 5-HT 2A kekahi hopena hopena i kekahi mau wahi e like me ka cortex ʻike a me ka orbitofrontal Cortex. Hoʻomaopopo mua ʻia kēia mea loaʻa no ka mea nui ma ke ʻano he pahuhopu o nā lāʻau psychedelic serotonergic e like me ka LSD a me ka mushroom psilocybin. Ma hope ua hoʻi hou i ke kūlana kiʻekiʻe no ka mea ua ʻike ʻia e lawelawe ana, i ka hapa iki, i ka hana a nā lāʻau antipsychotic he nui, ʻo ia hoʻi nā mea ʻāpiki.
5-HT2A ʻelima: ʻO ka receptor 5-HT 2A kahi subtype o ka receptor 5-HT 2 e pili ana i ka ʻohana receptor serotonin a he receptor hui pū ʻia me G protein (GPCR). ʻO ka receptor 5-HT 2A kahi mea loaʻa i ka ʻili pūnaewele. Pōkole ʻo 5-HT no 5-hydroxy-tryptamine, ʻo ia ka serotonin. ʻO kēia ka subtype receptor recitatory nui i waena o nā GPCRs no ka serotonin, ʻoiai ʻo 5-HT 2A kekahi hopena hopena i kekahi mau wahi e like me ka cortex ʻike a me ka orbitofrontal Cortex. Hoʻomaopopo mua ʻia kēia mea loaʻa no ka mea nui ma ke ʻano he pahuhopu o nā lāʻau psychedelic serotonergic e like me ka LSD a me ka mushroom psilocybin. Ma hope ua hoʻi hou i ke kūlana kiʻekiʻe no ka mea ua ʻike ʻia e lawelawe ana, i ka hapa iki, i ka hana a nā lāʻau antipsychotic he nui, ʻo ia hoʻi nā mea ʻāpiki.
5-HT2B ʻelima: 5-Hydroxytr Egyptamine receptor 2B ( 5-HT 2B ) i ʻike ʻia ma ke ʻano he receptor serotonin 2B he protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR2B He lālā ʻo 5-HT 2B o ka ʻohana receptor 5-HT 2 e hoʻopaʻa ana i ka serotonin neurotransmitter (5-hydroxytr Egyptamine, 5-HT).
5-HT2B ʻelima: 5-Hydroxytr Egyptamine receptor 2B ( 5-HT 2B ) i ʻike ʻia ma ke ʻano he receptor serotonin 2B he protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR2B He lālā ʻo 5-HT 2B o ka ʻohana receptor 5-HT 2 e hoʻopaʻa ana i ka serotonin neurotransmitter (5-hydroxytr Egyptamine, 5-HT).
5-HT2C mea loaʻa: ʻO ka receptor 5-HT 2C kahi subtype o ka receptor 5-HT e hoʻopaʻa ana i ka endotrousous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT). ʻO ia kahi mea loaʻa pūmua G hui pū ʻia (GPCR) i hui pū ʻia me G q / G 11 a me nā mea hoʻoliʻiliʻi neurotransmission Hōʻike ka HTR2C i ka hoʻopā'ālua o nā gen kanaka no ka receptor, aia i loko o nā kānaka aia ma ka X chromosome. ʻOiai he kope ko nā kāne kāne i ka ʻāpana a ma nā wahine kekahi o nā kope ʻelua o ka ʻāpana i hoʻopaʻa ʻia, hiki i nā polymorphism ma kēia receptor ke hoʻopili i nā kāne ʻelua i nā ʻokoʻa like ʻole.
5-HT2C mea loaʻa: ʻO ka receptor 5-HT 2C kahi subtype o ka receptor 5-HT e hoʻopaʻa ana i ka endotrousous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT). ʻO ia kahi mea loaʻa pūmua G hui pū ʻia (GPCR) i hui pū ʻia me G q / G 11 a me nā mea hoʻoliʻiliʻi neurotransmission Hōʻike ka HTR2C i ka hoʻopā'ālua o nā gen kanaka no ka receptor, aia i loko o nā kānaka aia ma ka X chromosome. ʻOiai he kope ko nā kāne kāne i ka ʻāpana a ma nā wahine kekahi o nā kope ʻelua o ka ʻāpana i hoʻopaʻa ʻia, hiki i nā polymorphism ma kēia receptor ke hoʻopili i nā kāne ʻelua i nā ʻokoʻa like ʻole.
5-HT2C mea loaʻa agonist: ʻO 5-HT 2C nā agonists nā mea loaʻa he papa o nā lāʻau e hoʻoheheʻe i nā mea loaʻa 5-HT 2C . Ua ʻimi ʻia lākou no ka mālama ʻana i nā ʻano he nui e like me ka momona, nā maʻi psychiatric, ka moe kolohe a me ka hoʻomau ʻole o ka urinary.
5-HT2C mea loaʻa agonist: ʻO 5-HT 2C nā agonists nā mea loaʻa he papa o nā lāʻau e hoʻoheheʻe i nā mea loaʻa 5-HT 2C . Ua ʻimi ʻia lākou no ka mālama ʻana i nā ʻano he nui e like me ka momona, nā maʻi psychiatric, ka moe kolohe a me ka hoʻomau ʻole o ka urinary.
5-HT2 mea loaʻa: ʻO nā mea loaʻa 5-HT 2 kahi ʻohana o nā mea loaʻa he 5-HT e hoʻopaʻa ana i ka endotrous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT). ʻO ka ʻohana 5-HT 2 ʻohana he ʻekolu mau ʻāpana protein G i hoʻohui ʻia (GPCRs) i hoʻopili ʻia iā G q / G 11 a me waena o neurotransmission excitatory, me 5-HT 2A , 5-HT 2B , a me 5-HT 2C . No ka ʻike hou aku, e ʻoluʻolu e ʻike i nā ʻatikala nui o kēlā me kēia subtypes:
5-HT2A ʻelima: ʻO ka receptor 5-HT 2A kahi subtype o ka receptor 5-HT 2 e pili ana i ka ʻohana receptor serotonin a he receptor hui pū ʻia me G protein (GPCR). ʻO ka receptor 5-HT 2A kahi mea loaʻa i ka ʻili pūnaewele. Pōkole ʻo 5-HT no 5-hydroxy-tryptamine, ʻo ia ka serotonin. ʻO kēia ka subtype receptor recitatory nui i waena o nā GPCRs no ka serotonin, ʻoiai ʻo 5-HT 2A kekahi hopena hopena i kekahi mau wahi e like me ka cortex ʻike a me ka orbitofrontal Cortex. Hoʻomaopopo mua ʻia kēia mea loaʻa no ka mea nui ma ke ʻano he pahuhopu o nā lāʻau psychedelic serotonergic e like me ka LSD a me ka mushroom psilocybin. Ma hope ua hoʻi hou i ke kūlana kiʻekiʻe no ka mea ua ʻike ʻia e lawelawe ana, i ka hapa iki, i ka hana a nā lāʻau antipsychotic he nui, ʻo ia hoʻi nā mea ʻāpiki.
5-HT2C mea loaʻa agonist: ʻO 5-HT 2C nā agonists nā mea loaʻa he papa o nā lāʻau e hoʻoheheʻe i nā mea loaʻa 5-HT 2C . Ua ʻimi ʻia lākou no ka mālama ʻana i nā ʻano he nui e like me ka momona, nā maʻi psychiatric, ka moe kolohe a me ka hoʻomau ʻole o ka urinary.
5-HT3 mea loaʻa: ʻO ka mea loaʻa 5-HT 3 i ka Cys-loop superfamily o nā kaha ion ligand-gated (LGICs) a no laila ʻokoʻa ke ʻano a me ka hana mai nā mea loaʻa ʻē aʻe 5-HT (5-hydroxytr Egyptamine, a i ʻole serotonin) mau mea loaʻa i loaʻa pū me ka protein G nā mea loaʻa leka uila. Koho kēia kele ion a koho i waena o ka neuronal depolarization a me ka hauʻoli i loko o nā kikowaena a me nā ʻōnaehana nūhou.
5-HT3 antagonist: ʻO ka antagonists 5-HT 3 , ʻike ʻole ʻia ma ke ʻano he " setrons ", kahi papa o nā lāʻau e hana ma ke ʻano he antagonists nā receptor ma ka receptor 5-HT 3 , kahi subtype o ka serotonin receptor i loaʻa i nā terminals o ka nerve vagus a ma kekahi mau wahi o lolo. Me nā hoʻokoe kaulana o ka alosetron a me ka cilansetron, i hoʻohana ʻia i ka mālama ʻana i ka maʻi huhū huhū, ʻo nā 5-HT 3 antagonist āpau he antiemetics, i hoʻohana ʻia i ka pale a me ka mālama ʻana i ka nausea a me ka luaʻi. Kūleʻa lākou i ka kaohi ʻana i ka nausea a me ka luaʻi i hana ʻia e ka chemotherapy maʻi ʻaʻai a manaʻo ʻia he kūlana gula no kēia kumu.
5-HT3 antagonist: ʻO ka antagonists 5-HT 3 , ʻike ʻole ʻia ma ke ʻano he " setrons ", kahi papa o nā lāʻau e hana ma ke ʻano he antagonists nā receptor ma ka receptor 5-HT 3 , kahi subtype o ka serotonin receptor i loaʻa i nā terminals o ka nerve vagus a ma kekahi mau wahi o lolo. Me nā hoʻokoe kaulana o ka alosetron a me ka cilansetron, i hoʻohana ʻia i ka mālama ʻana i ka maʻi huhū huhū, ʻo nā 5-HT 3 antagonist āpau he antiemetics, i hoʻohana ʻia i ka pale a me ka mālama ʻana i ka nausea a me ka luaʻi. Kūleʻa lākou i ka kaohi ʻana i ka nausea a me ka luaʻi i hana ʻia e ka chemotherapy maʻi ʻaʻai a manaʻo ʻia he kūlana gula no kēia kumu.
5-HT3 mea loaʻa: ʻO ka mea loaʻa 5-HT 3 i ka Cys-loop superfamily o nā kaha ion ligand-gated (LGICs) a no laila ʻokoʻa ke ʻano a me ka hana mai nā mea loaʻa ʻē aʻe 5-HT (5-hydroxytr Egyptamine, a i ʻole serotonin) mau mea loaʻa i loaʻa pū me ka protein G nā mea loaʻa leka uila. Koho kēia kele ion a koho i waena o ka neuronal depolarization a me ka hauʻoli i loko o nā kikowaena a me nā ʻōnaehana nūhou.
5-HT3 antagonist: ʻO ka antagonists 5-HT 3 , ʻike ʻole ʻia ma ke ʻano he " setrons ", kahi papa o nā lāʻau e hana ma ke ʻano he antagonists nā receptor ma ka receptor 5-HT 3 , kahi subtype o ka serotonin receptor i loaʻa i nā terminals o ka nerve vagus a ma kekahi mau wahi o lolo. Me nā hoʻokoe kaulana o ka alosetron a me ka cilansetron, i hoʻohana ʻia i ka mālama ʻana i ka maʻi huhū huhū, ʻo nā 5-HT 3 antagonist āpau he antiemetics, i hoʻohana ʻia i ka pale a me ka mālama ʻana i ka nausea a me ka luaʻi. Kūleʻa lākou i ka kaohi ʻana i ka nausea a me ka luaʻi i hana ʻia e ka chemotherapy maʻi ʻaʻai a manaʻo ʻia he kūlana gula no kēia kumu.
5-HT3 antagonist: ʻO ka antagonists 5-HT 3 , ʻike ʻole ʻia ma ke ʻano he " setrons ", kahi papa o nā lāʻau e hana ma ke ʻano he antagonists nā receptor ma ka receptor 5-HT 3 , kahi subtype o ka serotonin receptor i loaʻa i nā terminals o ka nerve vagus a ma kekahi mau wahi o lolo. Me nā hoʻokoe kaulana o ka alosetron a me ka cilansetron, i hoʻohana ʻia i ka mālama ʻana i ka maʻi huhū huhū, ʻo nā 5-HT 3 antagonist āpau he antiemetics, i hoʻohana ʻia i ka pale a me ka mālama ʻana i ka nausea a me ka luaʻi. Kūleʻa lākou i ka kaohi ʻana i ka nausea a me ka luaʻi i hana ʻia e ka chemotherapy maʻi ʻaʻai a manaʻo ʻia he kūlana gula no kēia kumu.
5-HT4 palapala loaʻa: 5-Hydroxytr Egyptamine receptor 4 kahi protein i loko o ke kanaka i hoʻopili ʻia e ka ʻāpana HTR4 .
5-HT4 palapala loaʻa: 5-Hydroxytr Egyptamine receptor 4 kahi protein i loko o ke kanaka i hoʻopili ʻia e ka ʻāpana HTR4 .
5-HT4 palapala loaʻa: 5-Hydroxytr Egyptamine receptor 4 kahi protein i loko o ke kanaka i hoʻopili ʻia e ka ʻāpana HTR4 .
ʻO agonist receptor Serotonin: ʻO kahi agonist receptor agonist kahi agonist o hoʻokahi a ʻoi paha o nā serotonin receptor. Hoʻopili lākou i nā mea loaʻa serotonin i kahi ʻano like me ka serotonin, kahi neurotransmitter a me ka hormone a me ka ligand endogenous o nā serotonin receptor.
5-HT4 palapala loaʻa: 5-Hydroxytr Egyptamine receptor 4 kahi protein i loko o ke kanaka i hoʻopili ʻia e ka ʻāpana HTR4 .
5-HT5A ʻelima: 5-Hydroxytr Egyptamine (serotonin) receptor 5A , ʻike ʻia ʻo HTR5A , kahi protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR5A . ʻO nā agonists a me nā antagonists no nā mea loaʻa he 5-HT, a me nā mea hoʻopaʻa i ka serotonin, loaʻa nā promnesic (hoʻolauna hoʻomanaʻo) a me / a i ʻole nā ​​hopena anti-amnesic ma lalo o nā ʻano ʻokoʻa, a pili pū nā mea loaʻa 5-HT me nā loli neural.
5-HT5A ʻelima: 5-Hydroxytr Egyptamine (serotonin) receptor 5A , ʻike ʻia ʻo HTR5A , kahi protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR5A . ʻO nā agonists a me nā antagonists no nā mea loaʻa he 5-HT, a me nā mea hoʻopaʻa i ka serotonin, loaʻa nā promnesic (hoʻolauna hoʻomanaʻo) a me / a i ʻole nā ​​hopena anti-amnesic ma lalo o nā ʻano ʻokoʻa, a pili pū nā mea loaʻa 5-HT me nā loli neural.
5-HT5A ʻelima: 5-Hydroxytr Egyptamine (serotonin) receptor 5A , ʻike ʻia ʻo HTR5A , kahi protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR5A . ʻO nā agonists a me nā antagonists no nā mea loaʻa he 5-HT, a me nā mea hoʻopaʻa i ka serotonin, loaʻa nā promnesic (hoʻolauna hoʻomanaʻo) a me / a i ʻole nā ​​hopena anti-amnesic ma lalo o nā ʻano ʻokoʻa, a pili pū nā mea loaʻa 5-HT me nā loli neural.
5-HT5B loaʻa: ʻO ka mea loaʻa 5-HT 5B kahi protein reseptor 5-HT a me ka ʻāpana e hoʻopili iā ia. ʻIke ʻia ka protein i loko o nā rodents, akā ʻaʻole i loko o nā kānaka, no ka mea, hooki nā codons i ke kaʻina coding o ka ʻaoʻao e pale i ka ʻāpana mai ka hōʻike ʻana i kahi protein i hana ʻia Manaʻo ʻia ua hoʻololi ʻia ka hana o ka mea loaʻa 5-HT 5B i nā kānaka e kekahi papa ʻē aʻe o 5-HT receptor. ʻO ka mea loaʻa he 5-HT 5B kahi mea loaʻa i ka protein G. Hōʻike nui ʻia ʻo 5-HT 5B receptor mRNA i ka habenula, hippocampus a me ka ʻoliva haʻahaʻa o ka lolo iole. ʻIke ʻia nā agonists no 5-HT 5B me ergotamine a me LSD. ʻO nā antagonists e ʻike ʻia me ka methiothepin.
5-HT5A ʻelima: 5-Hydroxytr Egyptamine (serotonin) receptor 5A , ʻike ʻia ʻo HTR5A , kahi protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana HTR5A . ʻO nā agonists a me nā antagonists no nā mea loaʻa he 5-HT, a me nā mea hoʻopaʻa i ka serotonin, loaʻa nā promnesic (hoʻolauna hoʻomanaʻo) a me / a i ʻole nā ​​hopena anti-amnesic ma lalo o nā ʻano ʻokoʻa, a pili pū nā mea loaʻa 5-HT me nā loli neural.
5-HT6 palapala loaʻa: ʻO ka receptor 5HT 6 kahi subtype o ka receptor 5HT e hoʻopaʻa ana i ka endotrous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5HT). ʻO ia kahi mea loaʻa pūmua G hui pū ʻia (GPCR) i hui pū ʻia me G s a hoʻopili i ka neurotransmission excitatory. Hōʻike ʻo HTR6 i ka hoʻopāʻā ʻana o nā gen kanaka no ka mea loaʻa.
5-HT6 palapala loaʻa: ʻO ka receptor 5HT 6 kahi subtype o ka receptor 5HT e hoʻopaʻa ana i ka endotrous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5HT). ʻO ia kahi mea loaʻa pūmua G hui pū ʻia (GPCR) i hui pū ʻia me G s a hoʻopili i ka neurotransmission excitatory. Hōʻike ʻo HTR6 i ka hoʻopāʻā ʻana o nā gen kanaka no ka mea loaʻa.
5-HT7 ʻelima: ʻO ka receptor 5-HT 7 kahi lālā o ka superfamily GPCR o nā ʻelima ʻili a ua hoʻoulu ʻia e ka neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT) Hoʻohui ʻia ka mea loaʻa 5-HT 7 iā G s (stimulate i ka hana o ka intracellular signaling molekule cAMP) a ua hōʻike ʻia i loko o nā ʻano like ʻole o ke kanaka, ʻo ia hoʻi i ka lolo, ka gastrointestinal tract, a me nā moku koko like ʻole. ʻO kēia receptor kahi pahuhopu hoʻomohala lāʻau no ka mālama ʻana i nā maʻi maʻi. Hoʻokomo ʻia ka mea loaʻa 5-HT 7 e ka ʻāpana HTR7 , i kope ʻia i loko o nā kānaka i 3 mau ʻokoʻa splice ʻokoʻa.
5-HT7 ʻelima: ʻO ka receptor 5-HT 7 kahi lālā o ka superfamily GPCR o nā ʻelima ʻili a ua hoʻoulu ʻia e ka neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT) Hoʻohui ʻia ka mea loaʻa 5-HT 7 iā G s (stimulate i ka hana o ka intracellular signaling molekule cAMP) a ua hōʻike ʻia i loko o nā ʻano like ʻole o ke kanaka, ʻo ia hoʻi i ka lolo, ka gastrointestinal tract, a me nā moku koko like ʻole. ʻO kēia receptor kahi pahuhopu hoʻomohala lāʻau no ka mālama ʻana i nā maʻi maʻi. Hoʻokomo ʻia ka mea loaʻa 5-HT 7 e ka ʻāpana HTR7 , i kope ʻia i loko o nā kānaka i 3 mau ʻokoʻa splice ʻokoʻa.
5-Hydroxytr Egyptophan: ʻO 5-Hydroxytr Egyptophan ( 5-HTP ), a i ʻike ʻia he oxitriptan , kahi amino acid a me ka precursor kemika e kū nei a me kahi interabate metabolic i ka biosynthesis o ka serotonin neurotransmitter.
ʻO Bufotenidine: ʻO Bufotenidine , i ʻike ʻia ʻo 5-hydroxy- N , N , N -trimethyltr Egyptammonium ( 5-HTQ ), he lāʻau make e pili ana i ka bufotenin, serotonin, a me nā tryptamines ʻē aʻe i loaʻa i loko o ka onaona o nā ʻano toads. Hana ia ma ke ʻano he agonist receptor 5-HT 3 i wae ʻia, a ua hoʻohana ʻia i ka noiʻi ʻepekema e hoʻopaʻa i ka hana a ka mea loaʻa 5-HT 3 , ʻoiai ua kaupalena ʻia kēia hoʻohana e ka ʻoiaʻiʻo, ma ke ʻano he amine quaternary, ʻaʻole hiki e maʻa koke i ka pale ā-lolo.
Lawe Serotonin: ʻO ka mea lawe i ke serotonin i ʻike ʻia ma ke ʻano he sodium lawe i ka serotonin transporter a me ka ʻohana mea lawe lawe 6 lālā 4 he protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana SLC6A4 . ʻO SERT kahi ʻano o ka protein transporter monoamine e lawe i ka serotonin mai ka synaptic cleft i hope i ka neuron presynaptic.
5-HTTLPR: ʻO 5-HTTLPR kahi wahi polymorphic hou hou i SLC6A4 , ka moʻokūʻauhau i nā code no ka mea lawe serotonin. Ma muli o ka ʻike ʻia ʻana o ka polymorphism ma waena o nā makahiki 1990, ua hoʻokolokolo nui ʻia ia, e laʻa me nā maʻi neuropsychiatric. ʻatikala i ʻōlelo ʻia "ʻoi aku ma luna o 300 mau ʻano hana, psychiatric, pharmacogenetic a me nā palapala genetics lapaʻau ʻē aʻe" i kālailai ʻia ka polymorphism. ʻOiai kūkākūkā pinepine ʻia ma ke ʻano he laʻana o ka launa pūnaʻāina, paio ʻia kēia paio.
5-HT1D mea loaʻa: 5-hydroxytr Egyptamine (serotonin) receptor 1D , i ʻike ʻia ʻo HTR1D , he mea loaʻa he 5-HT, akā hōʻike pū kekahi i ka gen kanaka e hoʻopili ana iā ia. Hana ʻo 5-HT 1D ma ka ʻōnaehana ʻōnaehana waena, a hoʻopili i ka locomotion a me ka hopohopo. Hoʻokomo pū ia i ka vasoconstriction vascular i ka lolo.
5-HT3 mea loaʻa: ʻO ka mea loaʻa 5-HT 3 i ka Cys-loop superfamily o nā kaha ion ligand-gated (LGICs) a no laila ʻokoʻa ke ʻano a me ka hana mai nā mea loaʻa ʻē aʻe 5-HT (5-hydroxytr Egyptamine, a i ʻole serotonin) mau mea loaʻa i loaʻa pū me ka protein G nā mea loaʻa leka uila. Koho kēia kele ion a koho i waena o ka neuronal depolarization a me ka hauʻoli i loko o nā kikowaena a me nā ʻōnaehana nūhou.
Aralkylamine N-acetyltransferase: ʻO Aralkylamine N -acetyltransferase ( AANAT ), i kapa ʻia ʻo arylalkylamine N -acetyltransferase a i ʻole serotonin N -acetyltransferase (SNAT), kahi ʻākena e pili ana i ka lā / pō hana rhythmic o melatonin, e ka hoʻololi ʻana o ka serotonin. Aia ia i loko o nā kānaka i hoʻopili ʻia e ka ʻohana ~ 2.5 kb AANAT i loaʻa nā ʻehā exons, aia ma ka chromosome 17q25. Unuhi ʻia ka moʻokūʻauhau i kahi 23 kDa nui enzyme. Mālama maikaʻi ʻia ia ma o ka ulu ʻana a ʻo ke ʻano o ke protein he 80 pakeneka like ia me nā hipa a me nā ʻiole AANAT. He enzyme hilinaʻi acetyl-CoA ia o ka ʻohana e pili ana i ka GCN5 o N -acetyltransferases (GNATs). Hāʻawi paha ia i nā maʻi genetactorial genetika e like me ka loli i hoʻololi ʻia i ka hiamoe / pōʻaiapuni a ke hele nei ka noiʻi me ka pahuhopu o ka hoʻomohala ʻana i nā lāʻau e hoʻoponopono i ka hana AANAT
ʻO Seragonin receptor antagonist: ʻO ka antagonist serotonin , a i ʻole kahi antagonist receptor serotonin , kahi lāʻau i hoʻohana ʻia e kāohi i ka hana ma nā serotonin (5-HT) mau mea loaʻa.
ʻO 5-HT ka mea loaʻa: ʻO nā mea loaʻa ʻo 5-HT , nā mea loaʻa he 5-hydroxytr Egyptamine , a i ʻole nā mea loaʻa serotonin , kahi hui o nā mea loaʻa pū kekahi protein G a me nā kaha ion ligand-gated i loaʻa i nā ʻōnaehana kikowaena a me nā ʻaoʻao āpau. Hoʻopili lākou i nā neurotransmission excitatory a me inhibitory. Hoʻoulu ʻia nā mea hoʻolauna serotonin e ka neurotransmitter serotonin, e hana nei ma ke ʻano he ligand maoli.
5-HT2C mea loaʻa: ʻO ka receptor 5-HT 2C kahi subtype o ka receptor 5-HT e hoʻopaʻa ana i ka endotrousous neurotransmitter serotonin (5-hydroxytr Egyptamine, 5-HT). ʻO ia kahi mea loaʻa pūmua G hui pū ʻia (GPCR) i hui pū ʻia me G q / G 11 a me nā mea hoʻoliʻiliʻi neurotransmission Hōʻike ka HTR2C i ka hoʻopā'ālua o nā gen kanaka no ka receptor, aia i loko o nā kānaka aia ma ka X chromosome. ʻOiai he kope ko nā kāne kāne i ka ʻāpana a ma nā wahine kekahi o nā kope ʻelua o ka ʻāpana i hoʻopaʻa ʻia, hiki i nā polymorphism ma kēia receptor ke hoʻopili i nā kāne ʻelua i nā ʻokoʻa like ʻole.
ʻO 5-HT ka mea loaʻa: ʻO nā mea loaʻa ʻo 5-HT , nā mea loaʻa he 5-hydroxytr Egyptamine , a i ʻole nā mea loaʻa serotonin , kahi hui o nā mea loaʻa pū kekahi protein G a me nā kaha ion ligand-gated i loaʻa i nā ʻōnaehana kikowaena a me nā ʻaoʻao āpau. Hoʻopili lākou i nā neurotransmission excitatory a me inhibitory. Hoʻoulu ʻia nā mea hoʻolauna serotonin e ka neurotransmitter serotonin, e hana nei ma ke ʻano he ligand maoli.
ʻO 5-HT ka mea loaʻa: ʻO nā mea loaʻa ʻo 5-HT , nā mea loaʻa he 5-hydroxytr Egyptamine , a i ʻole nā mea loaʻa serotonin , kahi hui o nā mea loaʻa pū kekahi protein G a me nā kaha ion ligand-gated i loaʻa i nā ʻōnaehana kikowaena a me nā ʻaoʻao āpau. Hoʻopili lākou i nā neurotransmission excitatory a me inhibitory. Hoʻoulu ʻia nā mea hoʻolauna serotonin e ka neurotransmitter serotonin, e hana nei ma ke ʻano he ligand maoli.
Ke hoʻokuʻu nei ʻo Serotonin i ka ʻākena: ʻO kahi agotonin hoʻokuʻu hoʻokuʻu ( SRA ) kahi ʻano lāʻau e hoʻowalewale i ka hoʻokuʻu ʻia ʻana o ka serotonin i loko o ka puʻu neurapt synaptic. ʻO kahi mea hoʻokuʻu hoʻokuʻu serotonin koho ( SSRA ) kahi SRA me ka mea nui a ʻaʻohe hopena i ka hana ʻana i nā efflux neurotransmitter ma nā ʻano neona monoons like ʻole.
Ke hoʻokuʻu nei ʻo Serotonin i ka ʻākena: ʻO kahi agotonin hoʻokuʻu hoʻokuʻu ( SRA ) kahi ʻano lāʻau e hoʻowalewale i ka hoʻokuʻu ʻia ʻana o ka serotonin i loko o ka puʻu neurapt synaptic. ʻO kahi mea hoʻokuʻu hoʻokuʻu serotonin koho ( SSRA ) kahi SRA me ka mea nui a ʻaʻohe hopena i ka hana ʻana i nā efflux neurotransmitter ma nā ʻano neona monoons like ʻole.
Serotonin maʻi maʻi: ʻO Serotonin Syndrome ( SS ) kahi hui o nā ʻōuli e kū aʻe me ka hoʻohana ʻana o kekahi mau lāʻau serotonergic a i ʻole nā ​​lāʻau. Hiki ke kaʻina o nā hōʻailona mai ke akahai a i ke koʻikoʻi, e like me ka make ʻana o ka make. ʻO nā ʻōuli ma nā hihia maʻalahi me ke kiʻekiʻe o ke koko a me ka wikiwiki o ka naʻau; maʻamau me ka ʻole o ke kuni. ʻO nā ʻōuli ma nā hihia kaulike e komo pū me ka mahana o ke kino, ka hoʻonāukiuki, hoʻonui i nā reflexes, haʻalulu, ka hou, nā haumāna i hoʻonui ʻia, a me ka diarrhea I nā hihia koʻikoʻi hiki ke hoʻonui i ka mahana o ke kino ma mua o 41.1 ° C (106.0 ° F). Komo pū nā pilikia me ka hopu ʻana a me ka hōʻemi nui ʻana o nā mākala.
Lawe Serotonin: ʻO ka mea lawe i ke serotonin i ʻike ʻia ma ke ʻano he sodium lawe i ka serotonin transporter a me ka ʻohana mea lawe lawe 6 lālā 4 he protein i loko o nā kānaka i hoʻopili ʻia e ka ʻāpana SLC6A4 . ʻO SERT kahi ʻano o ka protein transporter monoamine e lawe i ka serotonin mai ka synaptic cleft i hope i ka neuron presynaptic.
Hoʻouka Kaha 5-poʻo: ʻO 5-Headed Shark Attack kahi kiʻi ʻoniʻoni hoʻoweliweli sci-fi 2017 i hana ʻia e The Asylum i hui pū ʻia me Syfy. Me ka hōʻike ʻana i kahi manō me nā poʻo ʻelima, ʻo ke kiʻi ʻekolu kēia o nā moʻo kiʻi ʻo Multi-Headed Shark Attack, ma hope o 2-Headed Shark Attack a me 3-Headed Shark Attack a ma mua o 6-Headed Shark Attack , me kēia kiʻi ʻoniʻoni me nā manō ʻehā ʻelima poʻo poʻo ʻelima.
5-Histidylcysteine ​​sulokside synthase: ʻO 5-Histidylcysteine ​​sulokside synthase ka enzyme mua i ka biosynthesis o ovothiol, catalyzing ka hoʻohui oxidative o cysteine ​​i histidine, e hana ana i 5-histidylcysteine ​​suloxide. ʻIke ʻia ka ʻenemema ma Trypanosome, kahi i loaʻa iā SAM kahi methyl transferase e pili ana, a hoʻohui i kahi hui methyl i N1.
Ikehu 5-hola: ʻO 5-hola ka ikehu he "pana pana" i hana ʻia e ʻAmelika e hana ʻia e Living Essentials LLC. Ua hoʻokumu ʻia ka hui e CEO Manoj Bhargava a ua hoʻokumu ʻia i 2004.
5-Hour Energy (paikikala paikikala): ʻO 5-Hour Energy kahi kime holo paikikala UCI Continental i hoʻokumu ʻia ma 2009 i United States.
5-hola ikehu 200: 5-hola Energy 200 hiki ke kuhikuhi i nā lāhui NASCAR aʻe: 5-hola ʻEnehana 200, Ke heihei / hoʻomaka lā kauwela Nationwide Series heihei ma Dover International Speedway i mālama ʻia ma waena o 2011 a me 2013 5-hola Energy 200, Ke heihei Nationwide Series ma Dover International Speedway i mālama ʻia e hoʻomaka ana i ka 2013
5-Nā hola ikehu 250: ʻO ka 5-Hour Energy 250 he heihei NASCAR Nationwide Series i mālama ʻia ma Gateway International Raceway ma Madison, Ilinoi.
ʻO Juglone: ʻO Juglone , i kapa ʻia hoʻi ʻo 5-hydroxy-1,4-naphthalenedione (IUPAC) kahi hui kūmole me ka mole mole C 10 H 6 O 3 . I ka ʻoihana meaʻai, ʻike ʻia ka juglone ʻo CI Natural Brown 7 a me CI 75500 . He ʻole ia i ka benzene akā hiki ke hoʻoheheʻe ʻia i ka dioxane, kahi e crystallize ai ʻo ia e like me nā nila melemele. He isomer ʻo ia o ka lawone, ʻo ia ka hui pū ʻia i ka lau henna.
5-Hydroxy-2 (5H) -furanone: ʻO 5-Hydroxy-2 (5 H ) -furanone kahi furanone i loaʻa mai i ka oxidation o furfural e hoʻohana ana i ka oxygen singlet. Lawe ʻia kēia oxidation i methanol a i ʻole ethanol me kahi sensitizer e like me ka methylene blue a i ʻole Rose bengal. Hōʻike ʻia ke ʻano o kēia hopena ma lalo.
Eugenin: ʻO Eugenin kahi aʻa chromone, kahi phenolic compound i loaʻa i nā cloves. ʻO ia kekahi o nā hui e kuleana no ka ʻawaʻawa i nā kāloti.
Eugenin: ʻO Eugenin kahi aʻa chromone, kahi phenolic compound i loaʻa i nā cloves. ʻO ia kekahi o nā hui e kuleana no ka ʻawaʻawa i nā kāloti.
ʻO Techtochrysin: ʻO Techtochrysin kahi hui kemika . ʻO ia kahi flavone O-methylated, kahi flavonoid i hoʻokaʻawale ʻia mai Prunus cerasus , ka cherry ʻawaʻawa, kahi mea kanu maoli i ka hapa nui o ʻEulopa a me ka hema hema o ʻAsia.
ʻO Bufotenin: ʻO Bufotenin kahi huahana tryptamine e pili ana i ka neurotransmitter serotonin. He alkaloid ia i loaʻa i kekahi ʻano o nā toads, nā mea kanu a me nā mea kanu kiʻekiʻe.
Alpha-Methylserotonin: α-Methylserotonin ( αMS ), ʻike ʻia ʻo α-methyl-5-hydroxytr Egyptamine ( α-methyl-5-HT ) a i ʻole 5-hydroxy-α-methyltr Egyptamine ( 5-HO-αMT ), kahi pākana tryptamine pili loa i ka serotonin neurotransmitter (5-HT). Hana ia ma ke ʻano he agonist receptor serotonin non-selective a ua hoʻohana nui ʻia i ka noiʻi ʻepekema e hoʻopaʻa i ka hana o ka ʻōnaehana serotonin.
Serotonin: ʻO Serotonin a i ʻole 5-hydroxytr Egyptamine ( 5-HT ) kahi neurotransmitter monoamine. He paʻakikī a multifaceted kāna hana biology, hoʻololi i ka naʻau, ʻike, uku, aʻo, hoʻomanaʻo, a me nā hanana physiological e like me ka luaʻi a me ka vasoconstriction.
5-Hydroxycytosine: ʻO 5-Hydroxycytosine kahi ʻano oxidized o cytosine e pili ana me ka hoʻonui pinepine ʻana o C i nā hoʻololi hoʻololi T, me kekahi C a G transversions. ʻAʻole ia e kekeʻe i ka mole mole DNA a mākaukau koke ʻia e nā polymerases DNA replicative.
5-Hydroxyeicosanoid dehydrogenase: 5-Hydroxyeicosanoid dehydrogenase ( 5-HEDH ) a i ʻole ke kūlana maʻamau, nicotinamide adenine dinucleotide phosphate (NADP + ) -e kaukaʻi dehydrogenase, kahi enzyme e hoʻopili i kahi huahana eicosanoid o arachidonate 5-lipoxygenase (5-LOX), 5 ( S ) -hydro -6 S , 8 Z , 11 Z , 14 Z -eicosatetraenoic acid (ie 5- ( S ) -HETE; e ʻike i 5-HETE) i kāna analog 5-keto, 5-oxo-eicosatetraenoic acid (ie 5-oxo-6 S , 8 Z , 11 Z , 14 Z -eicosatetraenoic acid a i ʻole 5-oxo-ETE). Hana pū ia i ka ʻaoʻao huli, metabolizing 5-oxo-ETE i 5 ( S ) -HETE. No ka mea ʻo 5-oxo-ETE 30-100-pā iʻoi aku ka ikaika ma mua o 5 ( S ) -HETE i ka hoʻonāukiuki ʻana i nā ʻano pūnaewele like ʻole, ua manaʻo ʻia ʻo 5-HEDH i mea hoʻokele a me nā mea hoʻolaha o 5 ( S ) HETE a no laila nā hopena o 5-LOX ma hana paʻalima. ʻOiai ua loiloi ʻia ʻo 5-HEDH i kahi ākea o nā pūnaewele paʻa ʻole a me nā hoʻomākaukau microsome crude, ʻaʻole ia i loiloi ʻia no kāna hanana, no kona ʻāpana, ma ke ʻano maʻemaʻe; Eia kekahi, ua alakaʻi ʻia ka hapa nui o nā noiʻi e pili ana iā ia i nāʻiʻo o ke kanaka.
5-Hydroxyeicosatetraenoic acid: 5-Hydroxyeicosatetraenoic acid kahi eicosanoid, ʻo ia kahi metabolite o ka waikawa arachidonic. Hana ʻia ia e nā ʻano pūnaewele like ʻole i loko o nā kānaka a me nā ʻano holoholona ʻē aʻe. Hiki i kēia mau hunaola ke hoʻopili i ka 5 ( S ) -HETE i 5-oxo-eicosatetraenoic acid (5-oxo-ETE), 5 ( S ), 15 ( S ) -dihydroxyeicosatetraenoic acid, a i ʻole 5-oxo-15-hydroxyeicosatetraenoic acid .
5-Hydroxyeicosatetraenoic acid: 5-Hydroxyeicosatetraenoic acid kahi eicosanoid, ʻo ia kahi metabolite o ka waikawa arachidonic. Hana ʻia ia e nā ʻano pūnaewele like ʻole i loko o nā kānaka a me nā ʻano holoholona ʻē aʻe. Hiki i kēia mau hunaola ke hoʻopili i ka 5 ( S ) -HETE i 5-oxo-eicosatetraenoic acid (5-oxo-ETE), 5 ( S ), 15 ( S ) -dihydroxyeicosatetraenoic acid, a i ʻole 5-oxo-15-hydroxyeicosatetraenoic acid .